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By 1800 days, cumulative incidence was 4.39% (95% CI: 3.605.36) versus 6.07% (95% CI: 5.197.09) (log-rank P =0.013)

Defining trained immunity and its role in health and disease

High levels of intracellular iron in non-parenchymal cells induce ferroportin-mediated degradation, maintaining the high levels of intracellular iron and further stimulating BMP6 production in a positive feedback loop