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(2) It is engineered to favor growth hormone release rather than opioid activity, apparently by targeting ghrelin (growth hormone secretagogue) receptors instead of classical opioid receptors

In research literature, this pairing is distinct for its focus on metabolic optimization

In fasted healthy normal weight patients, GLP-1 (7-36) amide injection reduced fMRI activity induced by food images, in all brain areas studied (amygdala, insula, caudate, NAc, orbitofrontal cortex, and putamen), compared to saline injection [43]