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Those taking SGLT2 inhibitors should be particularly cautious with very low-carbohydrate diets due to the increased risk of euglycaemic diabetic ketoacidosis

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Pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase (AKD) play pivotal roles in glycolysis and the Krebs cycle, respectively, since AKD, in the Krebs cycle, helps maintain neurotransmitter levels and supports protein synthesis (37, 39, 40)