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A healthy anus contains two sphincter muscles (internal and external) that work together to control bowel movements, with the internal sphincter relaxing automatically and the external under conscious control

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The authors found that the majority of opioid overdose deaths also involved other drugs, and that individuals with other psychiatric disorders (in addition to substance use disorder) were more likely to overdose with opioids and stimulants than with opioids alone

It is often accompanied by chronic fatigue, muscle loss, osteoporosis, depressive states or increased risk of cardiometabolic disorders