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Xue et al., 2004

Another 2020 meta-analysis found that Berberine supplementation led to significant reductions in body weight, BMI, and waist circumference

255 miR-30 inhibition triggers Notch1 signaling, pro-inflammatory cytokine (TNF and CCL2) production, and M1 macrophage polarization, indicating that miR-30 manipulation could be a therapeutic approach for reducing obesity-induced inflammation

Direct mechanisms may involve GLP-1 receptor activation on vascular endothelial cells, whilst indirect effects result from weight loss, improved glycaemic control, and reduced visceral adiposity, all of which independently lower inflammatory burden