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In addition, the role of glucose metabolism impairment was observed in a meta-analysis encompassing more than 1,700,000 patients, finding diabetic patients to have a 38% higher risk of development of PD (Yue et al., 2016), while in another meta-analysis on 86,000 PD patients, prediabetic patients were found to have a 4% higher risk of development of PD compared to individuals with no fasting glucose impairment ( 2.4 Mitochondrial dysfunction Mitochondria are crucial for insulin secretion from pancreatic cells, and their dysfunction contributes to impaired insulin secretion in T2DM

3.3.5 Testosterone Studies suggest that IF has substantial modulatory effects on the hypothalamic-pituitarygonadal (HPG) axis, influencing testosterone regulation and reproductive health [46, 55]

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