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Toxicol Lett 208:149161 Wu H, Zhang G (2017) Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice

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Bilirubin, a brown pigment produced by heme metabolism, overloads hepatic detoxification pathways, and also accumulates in plasma and tissues, causing jaundice