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Thomas L, Eckhardt M, Langkopf E et al (2008) (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors

[18] Ongoing communication with healthcare providers should include reporting of side effects such as persistent nausea, vomiting, diarrhea, abdominal pain, or signs of dehydration

Researchers also observed improvements in glucose metabolism markers

The starting dose and escalation schedule remain identical whether you are on metformin or not