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However, there are certain conditions in which vitamin B12 cannot be absorbed, for example, due to dietary insufficiency, malabsorption, or lack of intrinsic factor, hepatic stores are depleted, and deficiency ensues

In autoimmune diseases, amino acid metabolism-targeted interventions place greater emphasis on reducing pathological inflammation and promoting tissue repair, and therefore the available evidence is better organized from the perspective of feasible strategies and safety boundaries

Future studies are needed to dissect the cell-type specificity, temporal dynamics, and pathological consequences of these alternative DNA sensors in NDDs