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Pulsatile versus tonic GH release biology: Studies comparing the downstream biological consequences of pulsatile GH release (produced by short-acting GHRH analogues and GHRPs) versus tonic GH elevation (produced by long-acting GHRH-DAC variants or continuous GH infusion) established that pulsatile GH patterns are more potent drivers of hepatic IGF-1 production and anabolic GH signalling than equivalent total GH doses delivered continuously providing the physiological rationale for preserving pulsatile GH release characteristics in GH secretagogue research designs

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10.22074/CELLJ.2023.1989732.1234 182 SammadA.AhmedT.UllahK.HuL.LuoH.Alphayo KambeyP.et al (2024)