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The standard cytoprotective therapy exhibited only an incomplete effect [150]

Long-term acetyl-L-carnitine treatment in Alzheimer's disease Neurology 1991

Besides the direct cytotoxic and prooxidant effects of CP treatment, necroptosis could be induced indirectly through the combined action of cytokines, TNF-, TNF-related weak inducer of apoptosis, and IFN-, which were upregulated upon CP administration