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Despite greater improvements in glycemia (0.8% greater HbA1c reduction) and weight (7% greater weight loss), tirzepatide appeared to confer limited incremental cardiovascular benefit, raising questions about mechanism saturation or trial design constraints

These effects typically diminish with continued use and can be minimized through gradual dose titration and administration with meals

In men, reduced inflammation could aid sperm health but not change seminal protein composition that governs post-ejaculation function