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[16] [19] Subsequent analysis of SUSTAIN-6 data revealed that the increased risk was concentrated among patients who entered the trial with pre-existing diabetic retinopathy and experienced rapid improvements in glycemic control

It is majorly found circulating in the blood as GLP-1(7-36) amide that is produced primarily from three tissues of the human body: enteroendocrine L cells in the distal small bowel, cells in the pancreas, and the central nervous system ( Surprisingly, it took approximately 20 years from the discovery of GLP-1 to the authorized approval of worldwide utilized GLP-1 RAs

And finally 12mg for those randomized to the highest dose group

In recent years, GLP-1RAs have made significant advancements in the treatment of diabetes