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Postmenopausally, estrogen produced in the skin from the conversion of the adrenal precursors DHEA-S and DHEA becomes the primary source of estrogen

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To this degree, there are a low number of fingolimod associated malignancies that have emerged in clinical trials (Table 1) and in the post-clinical trial era, including melanoma, basal cell carcinoma, breast cancer, squamous cell carcinoma, large B cell lymphoma, ocular lymphoma, Merkel cell carcinoma, cutaneous CD30+ T-cell lymphoma and multiple myeloma