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As to whether taking berberine can aid in weight loss, the National Center for Complementary and Integrative Health noted some studies suggest that it might, but the evidence is not conclusive. The government agency cited a 2022 review of 18 studies that examined the effect of berberine on body weight and 23 that examined its effect on body mass index and found significant decreases in both weight and BMI in people who took berberine

It is a quaternary ammonium compound that the body synthesizes from the amino acids lysine and methionine, primarily in the liver, kidneys, and brain

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Some people who consume enough B-12 aren't able to absorb the vitamin