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When considering the debate of Mounjaro vs Zepbound, it's important to understand that although both drugs share the active ingredient tirzepatide, their purposes differ

The amount depends on your starting weight, treatment duration, and how consistently you practice the eating and exercise habits you built during medication

This was seen in association with increased baseline and post-prandial intact GLP-1 concentrations, reduced post-prandial glucagon levels and sustained insulin levels, which in the presence of lower glucose levels resulted in an increase of insulinogenic index as a sign of stimulated beta-cell function, which provided a first insight into the mechanism of action of DPP-4 inhibition in type 2 diabetes (Figure 4)

Whether adding GLP-1 to metformin provides better beta cell survival and delays disease progression remains to be validated