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Intranasal administration is valued as a non-invasive means of both systemic and local administration with good bioavailability, rapid onset, and targeted effects on the central nervous system [13, 14]

Cav-1 is crucial in maintaining vascular health but a paradoxical role of Cav-1 in cardiovascular pathophysiology has also been reported 19,38

Meanwhile, TB-500 is commonly used in research that explores cell movement and structural remodeling

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