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Therapeutic interventions in the vicious cycle of oxidative stress and neuroinflammation could offer a promising method for treating neurodegenerative diseases

Nevertheless, metabolomics offers a distinct advantage due to its direct representation of the biochemical phenotypes, which is particularly valuable in chronic conditions without established diagnostic tests

Additionally, metformin decreased the ratio of Cleared Caspase-3/Caspase-3, Cleaved Caspase-9, activated PINK1/Parkin mediated mitophagy, and prevented mitochondrial over fission and apoptosis

Models for nephrotoxicity screening Conventional in vitro models Until recently, researchers were left with only two options: in vitro cultures of primary human cells or the use of animal models, both having limitations