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Various bioanalytical methods, such as chromatographic techniques for determining drug plasma concentrations and metabolism 569,572 and imaging technology for estimating drug distribution, 573 are used, although each has limitations

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Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, Nadon NL, Wilkinson JE, Frenkel K, Carter CS, Pahor M, Javors MA, Fernandez E, Miller RA

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