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In Novo Nordisk's clinical late-phase trial for obesity without type 2 diabetes, which included more than 300 adults, the participants who took the pill once daily lost an average of 16.6% of their body weight, or 39 pounds , compared with 2.7%, or 6 pounds, for those on a placebo

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So it follows that continuing treatment helps preserve weight loss over time. Mir Ali, MD In the other placebo-controlled trial, SURMOUNT-MAINTAIN, the researchers investigated the efficacy and safety of maximum tolerated dose (MTD) tirzepatide and a lower 5 milligram (mg) dose for maintaining body weight reduction in adults with obesity