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Accessed Feb 5, 2026 at FDA Approves First Treatment to Reduce Risk of Serious Heart Problems Specifically in Adults with Obesity or Overweight

Tirzepatides (Mounjaro, Zepbound) are dual-agonist GLP-1 medications

Contact your GP or healthcare professional promptly if you experience: Persistent vomiting (unable to keep down fluids for more than 24 hours) Severe or prolonged diarrhoea (lasting more than 48 hours) Signs of dehydration : excessive thirst, dark urine, dizziness, reduced urine output Muscle weakness or cramps (particularly if severe or persistent) Irregular heartbeat or palpitations Unusual fatigue or lethargy Severe persistent abdominal pain, especially if radiating to the back (may suggest pancreatitis) Seek urgent medical attention (call 999 or attend A&E) if you develop: Severe chest pain or pressure Difficulty breathing or shortness of breath Severe muscle weakness affecting mobility Confusion or altered consciousness Fainting or collapse These symptoms may indicate significant electrolyte disturbances or other serious complications requiring immediate assessment

Common Early Semaglutide Side Effects How to Reduce Early Semaglutide Side Effects Many early side effects are influenced by how and what you eat while your body adjusts