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These animals were also subjected to the same environmental conditions and treatment protocols for a chronic 28-day administration study [2]
Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
Short cycles: Others employ DSIP in short-term cycles (e.g., 24 weeks) to avoid potential tolerance or adaptation
Weight Loss Efficacy: Cagrilintide has demonstrated significant weight loss potential, reducing food intake in animal studies with sustained effects at doses ranging from 1-10 nmol/kg
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