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The sequence structure of semaglutide is as follows: H-His 1 -Aib 2 -Glu 3 -Gly 4 -Thr 5 -Phe 6 -Thr 7 -Ser 8 -Asp 9 -Val 10 -Ser 11 -Ser 12 -Tyr 13 -Leu 14 -Glu 15 -Gly 16 -Gln 17 -Ala 18 -Ala 19 -Lys 20 (AEEA-AEEA--Glu-Octadecanedioic)-Glu 21 -Phe 22 -Ile 23 -Ala 24 -Trp 25 -Leu 26 -Val 27 -Arg 28 -Gly 29 -Arg 30 -Gly 31 -OH the existing synthesis process of the semaglutide comprises a preparation method of a product which is finished by combining a biological fermentation method and a chemical synthesis method selected in the original research (CN 101910193)

116-94), enacted on December 20, 2019

Manyari, D