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Conclusion In conclusion, it was showed for the first time that the pretreatment with Ab aqueous extract was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects as summarized in Figure 6

Fe 3+ is reduced to Fe 2+ by the ferrireductase activity of six-transmembrane epithelial antigens of the prostate 3 (STEAP3) in the endosome (Knutson, 2007)