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In addition, the NTS houses numerous neuropeptides that are capable of modulating HPA axis stress responses, including glucagon-like peptide-1 (GLP-1), somatostatin, substance P, neuropeptide Y and enkephalin [15, 18, 35]

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Cagrilintide has pharmacokinetic properties compatible with once-weekly administration, with an elimination terminal half-life ( t 1/2 ) of approximately 180 h (7.5 days) [7]