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Drug interaction guide Originally published 25 Jan 2026 DownloadDownload Share Language Discussion Audio Version Add to preferred sources on Google Taking these two medicines together is generally safe, but there is a minor interaction where atorvastatin might slightly increase the levels of levothyroxine in your blood

Lancet Diabetes Endocrinol 12:523534 Farooqi IS, Jebb SA, Langmack G et al (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency

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In addition, Lilly has said it should be able to scale up production of orforglipron without the same supply constraints that it's faced with Mounjaro and Zepbound