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An interesting study observed that lifelong aerobic-trained individuals (with 40 mlkg 1 min 1 VO 2 max) had higher blood Tregs markers concentrations (IL-10, forkhead box P3, and transforming growth factor-), low TNF-/IL-10 ratio associated with lower memory CD8 + T cells when compared to sedentary counterparts (with 29 mlkg 1 min 1 VO 2 max) (Minuzzi et al., 2017, 2018)