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Growth hormone secretagogues raise growth hormone and IGF-1, which has been studied mainly for effects on body composition and sleep in small groups

research shows no additional benefit above 1 mg daily Important: Doses above 1 mg (1,000 mcg) daily showed no additional metabolic benefits in clinical research

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Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells