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The Wegovy pill has been rigorously studied through Novo Nordisk's Phase 3 OASIS clinical trial programme, which enrolled approximately 1,300 adults with obesity or overweight with one or more related health conditions

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This data does and the message is that the patients who probably need GLP-1s most (obese, knee-pain, can't easily exercise) are exactly the ones losing the most lean mass on the more potent option

Oral formulations tend to have more acute gastrointestinal adverse effects, while subcutaneous administration may induce injection site discomfort [21]