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GLP-1 receptor agonists are medications that mimic this hormone, triggering a cascade of metabolic signals: they slow gastric emptying (keeping you full longer), reduce appetite through hypothalamic signaling, enhance insulin secretion in response to meals, and improve glucose homeostasis

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The sample size calculation was based on within-participant standard deviations for the logarithmic transformed ratios for icodec alone and for semaglutide alone with respect to total exposure from previous studies with icodec and semaglutide (ClinicalTrials.gov identifiers: NCT01730014 and NCT01766245, respectively)