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Finally, the effects of the selective MC 1 compound BMS-470539 showed signs of reducing the aggressive activity of synovial fibroblasts, an effect that translated into anti-arthritic actions in vivo , using the model of K/BxN serum transfer induced arthritis in mice ( 5 Challenges are directions towards melanocortin-based therapies targeting fibroblasts More than 60 years after the first report testing the role of the endogenous melanocortin ACTH on fibroblasts, a synthetic agonist is being trialled in a phase II study for the treatment of systemic sclerosis

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