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Direct-to-consumer marketing by telehealth platforms and compounding pharmacies has fueled demand for compounded GLP-1 therapies, promoted as affordable and personalized alternatives

Mannitol: It has not been demonstrated to be effective in managing cerebral edema caused by hyperammonemia and therefore, it should not be given, 43 strong recommendation, low quality evidence (1C)

TRT is generally a long-term treatment for men with clinically low testosterone, as levels often return to baseline if therapy is discontinued

Wegovy is approved for use on the NHS for a maximum of two years within these specialist services, as part of a comprehensive programme that includes dietary support, physical activity guidance, and behavioural intervention