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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Khademi S., Frye M.A., Jeckel K.M., Schroeder T., Monnet E., Irwin D.C., Cole P.A., Bell C., Miller B.F., Hamilton K.L

While these conditions do not contraindicate tirzepatide use and are not specifically identified as risk factors in the FDA label, patients with these conditions should receive thorough education about recognizing allergic symptoms

The peptide has been extensively studied in both preclinical models and human clinical trials, demonstrating consistent fat-reducing effects with a favorable safety profile