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Importantly, these phenotypes contrast with the non-inducible liver-specific Gclc KO mouse strain ( Gclc f/f Albumin-Cre), which develops liver failure and dies shortly after birth 30

This agent is selectively cytotoxic for abnormal melanocytes due to the reversible inhibition of tyrosinase and the inhibition of mitochondrial enzymes.136 It is applied twice a day for 2 to 12 weeks, depending on response.1 Treatment results have been highly variable,137139 and there is insufficient evidence to recommend its use over other modalities in clinical practice

Viola: [00:29:21] Sure