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PubMed Central , Tsin W., et al

As of 2025, retatrutide remains under clinical investigation and has not received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA) for routine clinical use in the UK

The most commonly reported adverse effects were mild to moderate headache and gastrointestinal symptoms including diarrhea, flatulence, nausea, and increased appetite

In addition, rats overexpressing GLP-1R showed improved learning and memory [77], whereas GLP-1 deficiency due to REM sleep deprivation can negatively impact anxiety and depression behaviors [78]