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Key lipid changes with GLP-1 receptor agonists include: Triglycerides: 15-25% reduction Total cholesterol: 3-8% reduction LDL cholesterol: 3-7% reduction HDL cholesterol: 2-5% increase Non-HDL cholesterol: 5-10% reduction The SELECT cardiovascular outcomes trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in patients with established cardiovascular disease who were receiving standard background care