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The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction

Rare but potentially serious side effects associated with GLP-1 receptor agonists include pancreatitis (inflammation of the pancreas), thyroid C-cell tumors, gallbladder problems and hypoglycemia (low blood sugar)

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The NADP + /NADPH Glo Assay Kit (Promega CAT NO: G9081) was used in accordance with the manufacturers instructions to determine the NADP + /NADPH levels in CRC cells