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When your blood sugar rises, specialized cells in your pancreas release insulin, a hormone Insulin tells your bodys cells to soak up glucose Your cells then either store glucose (as glycogen) for later use or metabolize it and use it for immediate energy Issues can occur when your body becomes insulin resistant, meaning you have a decreased response to insulin compared with someone with normal insulin sensitivity

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After an independent assessment of the selected literature, a follow-up conversation was conducted to address any discrepancies in the results, respond to questions and correct mistakes

Although the meta-regression did not significantly reduce the overall heterogeneity, it confirms that the high heterogeneity is driven by a combination of multiple factors rather than a single dominant study feature