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Screening for the presence of CKD is done in the stable outpatient setting because acute illnesses can transiently raise ACR and reduce eGFR

In a recent publication, it has been found that decreased prevalence of genus Adlercreutzia is associated with impaired barrier function in healthy relatives of CD patients [38]

These therapies should never be positioned as replacements for established antihypertensive agents such as ACE inhibitors, ARBs, or calcium channel blockers

In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 21% of the total weight of the formulation