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Fever, chills, or feeling generally unwell following the injection may indicate a systemic infection and necessitate urgent evaluation

The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%

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Precautions for DIY approaches DIY peptide products lack the quality controls of commercial formulations