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Tirzepatide expanded that conversation by targeting two hormone pathways instead of one

Because these drugs are used at higher doses for weight loss (compared to diabetes management), this is particularly important

This broader receptor engagement may translate to enhanced effects on reward circuitry beyond what single or dual agonists achieve

Additionally, restoring testosterone to physiologic ranges may improve several cardiovascular risk markers, including: Body composition Insulin sensitivity Lipid profiles TRT is not a cardiovascular drug, but it may favorably influence metabolic factors that contribute to heart disease risk