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DOI: 10.1080/07391102.2024.2304683

Elevated NNMT activitycommon in obesity and metabolic syndromedepletes NAD+ reserves by shunting nicotinamide into an excretory pathway rather than salvaging it for NAD+ biosynthesis

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The landmark cardiovascular outcomes trialsincluding SUSTAIN-6 for semaglutide and LEADER for liraglutidespecifically evaluated cardiovascular safety endpoints and did not report increased rates of venous thromboembolism compared to placebo, though it's important to note that VTE was not a primary endpoint in these studies