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While the exact mechanism isn't fully understood, headaches likely result from dehydration due to gastrointestinal side effects, blood glucose fluctuations, or metabolic changes during treatment initiation

Although the occurrence of different side-effects can lead to similar overall discontinuation rates, these findings raise the possibility that a large part of the treatment discontinuation is driven by patient-specific factors that affect treatment adherence across various types of drugs rather than drug-specific factors (including side-effects or oral vs subcutaneous administration)

Instead, we can only rely on indirect evidence to study these putative synapses including histology and tracing