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TAU is necessary for normal development, and its deficiency leads to defects in growth, tissue differentiation, and immune development
It mimics a natural gut hormone called glucagon-like peptide 1, which the body releases after meals to signal fullness, slow stomach emptying, and stabilize blood sugar
Moreover, ablation of these genes leads to the complete absence of hypaxial muscles (diaphragm, limbs, tongue), reflecting that HGF-MET have a pivotal role in proliferation and motility of these muscle progenitors (Maina et al., 1997, 1998
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