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(83), using the first crystal structure of G6PD, showed that the substitution of Arg with Leu at a highly conserved amino acid area near to the NADP + binding site in G6PD Canton affects the stability of the molecule

At this level of resolution, distinct conformations of the alkyl chain of S-hexyl glutathione are observed, reflecting the nonspecific nature of the hydrophobic substrate binding site (H-site)

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