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An example is B003-2A, a recently developed IGF-1R anti-idiotypic antibody antagonist, which abrogated the IGF-1R-mediated proliferation of ovarian cancer cells in vivo and in vitro and overcame resistance to cisplatin in ovarian cancer cell lines (64, 74)

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In an endothelin-1 (ET-1)-induced mouse model of RGC degeneration, LbGP demonstrated significant efficacy in preserving retinal nerve fiber layer (RNFL) thickness, maintaining RGC density, and restoring retinal functions

D.Tussing-HumphreysL.ChuA.et al (2020)