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Ping Li, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Core mechanisms of mitochondrial metabolic reprogramming Supplying flexible fuel: metabolic plasticity and therapeutic resistance CRC cells exhibit pronounced metabolic plasticity, enabling dynamic switching between glycolysis and mitochondrial OXPHOS in response to fluctuations in oxygen, glucose, and other metabolic substrates, thereby adopting a hybrid metabolic phenotype [6]

Limited evidence suggests that non-starchy vegetables may DECREASE the risk of: Estrogen receptor-negative (ER-) breast cancer Limited evidence suggests that non-starchy vegetables and fruits combined may DECREASE the risk of: Bladder cancer Ongoing Areas of Investigation Laboratory Research Flavonols (such as the quercetin in asparagus) influence gene expression and cell signaling in ways that increase antioxidant, anti-inflammatory and carcinogen-deactivating enzymes in studies of isolated cells and limited animal studies

It demonstrated increased efficiency of oxidative phosphorylation in rat mitochondria in vitro and possible antioxidant effects are also attributed to it