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The PEGylated peptides (23) and (24) retained the functional potency of native GLP-1 and its receptor binding characteristics, with (23) demonstrating the ability to lower blood glucose levels and reduce body weight over several days in non-human primates

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Specifically, 47 integrin regulates the localization of lymphocytes to the gut mucosa by binding to the gut-specific cell adhesion molecule mucosal addressin cell adhesion molecule-1 (MAdCAM-1), promoting the accumulation of immune cells at the site of inflammation, thereby exacerbating the intestinal inflammatory response [303, 304]