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In agreement with their single-drug effects, both (M+D)/2 and (M+D+V)/3 downregulated proteins linked to mitochondrial ATP synthesis and cell cycle ( Supplementary Figures S5 , S6
Compared with overt Cushings syndrome, patients with MACS exhibit similar but less pronounced phenotypic features, including abdominal adiposity, dorsocervical fat accumulation, characteristic skin changes, and proximal muscle weakness [177]
Together, they may enhance studies on recovery and metabolic health, though more research is needed to confirm these effects
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