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Initial dosing starts at 2.5 mg weekly to improve tolerability and is titrated every 4 weeks in 2.5 mg increments to a maximum of 15 mg, providing six dosing options: 2.5 mg 5 mg 7.5 mg 10 mg 12.5 mg 15 mg The initial low dose is not intended as the full therapeutic dose, but to reduce gastrointestinal side effects while patients adapt

And up until 15 years ago or so, all of these drugs which entered the market with great promise ultimately left the market due to lack of long-term efficacy or life-threatening complications from amphetamine that was used in the 1950s through

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